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Article number:
5600064
CAS No.:
20830-75-5
Formula:
C41H64O14
Chemical description:
4-[(3S,5R,8R,9S,10S,12R,13S,14S)-3-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-4,5-dihydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17
Synonyms:
Cardenolide
Molecular weight:
780,94 g/mol
Digoxin is derived from the leaves of a digitalis plant. Digoxin helps make the heart beat stronger and with a more regular rhythm. The second application of cardiac glycosides is cancer. Digoxin inhibits DNA topoisomerase I and II and increases the intracellular Ca2+ concentration. Digoxin induces cell cycle arrest through the upregulation of HIf-1alpha. Literature citation: http://dx.doi.org/10.5772/55381. Potential mode of action/Key words: Targeting DNA. Topoisomerase I & II inhibitor