for our newsletter!
Digoxin is derived from the leaves of a digitalis plant. Digoxin helps make the heart beat stronger and with a more regular rhythm. The second application of cardiac glycosides is cancer. Digoxin inhibits DNA topoisomerase I and II and increases the intracellular Ca2+ concentration. Digoxin induces cell cycle arrest through the upregulation of HIf-1alpha. Literature citation: http://dx.doi.org/10.5772/55381. Potential mode of action/Key words: Targeting DNA. Topoisomerase I & II inhibitor
Plant: Foxglove (Digitalis)
- Active ingredient from the cardiac glycoside group for the treatment of cardiac insufficiency and cardiac arrhythmias
- Increases the contractility and excitability of the heart muscle, reduces the frequency and slows down the conduction of excitation
- Digoxin (ATC C01AA05 [External Link] ) exerts numerous effects on the heart muscle. The most important of these include:increasing the force and speed of contraction (positive inotropic)
- Decrease in heart rate (negative chronotropic).
- Slowing of excitation conduction (negative dromotropic).
- Increase in excitability, especially of the ventricular muscles (positive bathmotropic)
- Consequence of the effect: increased stroke volume, which improves blood flow in the kidneys and increases urine output