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Article number:
5600174
CAS No.:
796073-70-6
Formula:
C38H54ClN3O10S2
Molecular weight:
812.43 g/mol
DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates, which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM. Potential mode of action/Key words: Targeting Tubulin, Tubulin inhibitor, Cytotoxic
Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...