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DM4

Article number:

5600231

CAS No.:

796073-69-3

Formula:

C38H54ClN3O10S

Chemical description:

Maytansine, N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)- (9CI, ACI)

Molecular weight:

780,37 g/mol

DM4, a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death.

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DM4

ADCs

Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...

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