O NH O O O OH H H N Cl O O O O N H O S S

DM4-SMe

Article number:

5600177

CAS No.:

796073-68-2

Formula:

C39H56ClN3O10S2

Molecular weight:

826.46 g/mol

DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM. Potential mode of action/Key words: Targeting Tubulin, Tubulin inhibitor

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DM4-SMe