Englerin A

Article number:


CAS No.:




Molecular weight:

442,56 g/mol

Englerin A from the plant Phyllanthus engleri is inducing both necrosis and apoptosis in Weing cells subsequent to a G2M accumulation of cells in the cell cylcle. Englerin A is causing a sustained increase in cytosolic aclcium levels. EA seems to exert its effect on Ewing cells throug a decrease in phosphorylation of WES-FLI1 and its ability to bind to DNA. This effect is mediated as least in part through a decrease in the levels of the calcium dependent PKC-ßI after a transient upregulation. We don`t sell for applications, infringing US Patent No.: 8410,292, Issued April 2, 2013, “Epoxy-Guaiane Derivatives and Treatment of Cancer”

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Englerin A


Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...

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