(-)-Epigallocatechin-3-gallate

Article number:

7501057

CAS No.:

989-51-5

Formula:

C22H18O11

Chemical description:

EGCG isolated from Camellia sinensis. Antioxidant, anticarcinogenic, antimutagenic, antineoplastic, neuroprotective effects.

Synonyms:

[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate; EGCG; (-)-Epigallocatechin gallate; (-)-Epigallocatechin-3-O-gallate; (-)-Epigallocatechol gallate; Epigallocatechin 3-gallate; Epigallocatechin-3-monogallate; L-Epigallocatechin gallate

Molecular weight:

458,37 g/mol

Epigallocatechin gallate, ellagic acid, and rosmarinic acid perturb dNTP pools and inhibit de novo DNA synthesis and proliferation of human HL-60 promyelocytic leukemia cells: Synergism with arabinofuranosylcytosine. Saiko P, Steinmann MT, Schuster H, Graser G, Bressler S, Giessrigl B, Lackner A, Grusch M, Krupitza G, Bago-Horvath Z, Jaeger W, Fritzer-Szekeres M, Szekeres T. Phytomedicine. 2015 Jan 15;22(1):213-22. doi: 10.1016/j.phymed.2014.11.017. Epub 2014 Dec 3. *** The Heat Shock Protein 90 Inhibitor, Epigallocatechin Gallate, has Anti-Cancer Activity in a Novel Human Prostate Cancer Progression Model. Moses MA, Henry EC, Ricke WA, Gasiewicz TA. Cancer Prev Res (Phila). 2015 Jan 20. pii: canprevres.0224.2014. [Epub ahead of print] *** Mechanism for the antibacterial action of epigallocatechin gallate (EGCg) on Bacillus subtilis. Nakayama M, Shimatani K, Ozawa T, Shigemune N, Tomiyama D, Yui K, Katsuki M, Ikeda K, Nonaka A, Miyamoto T. Biosci Biotechnol Biochem. 2015 Jan 3:1-10. [Epub ahead of print] *** Curcumin and Epigallocatechin Gallate Inhibit the Cancer Stem Cell Phenotype via Down-regulation of STAT3-NFKB Signaling. Chung SS, Vadgama JV. Anticancer Res. 2015 Jan;35(1):39-46. *** Nociceptive spinal cord neurons of laminae I-III exhibit oxidative stress damage during diabetic neuropathy which is prevented by early antioxidant treatment with epigallocatechin-gallate (EGCG). Raposo D, Morgado C, Pereira-Terra P, Tavares I. Brain Res Bull. 2015 Jan;110:68-75. doi: 10.1016/j.brainresbull.2014.12.004. Epub 2014 Dec 16.

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(-)-Epigallocatechin-3-gallate

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