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Epothilone A exhibits kinetics similar to paclitaxel by inducing tubulin polymerization in vitro and producing enhanced microtubule stability and bundling in cultured cells. In contrast to paclitaxel, Epothilone A exhibits a greater cytotoxicity against P-glycoprotein-expressing multidrug resistant cells (IC50= 20 nM for MDR CCRF-CEM/VBL100 cells). Epo A is cytotoxic to human T-24 bladder carcinoma cells (IC50 = 0.05 µM in vitro) but has poor pharmacological properties and is 2-fold less potent in stabilizing microtubules compared to Epothilone B. (-)-Epothilone A is a microtubule stabilizing agent. (-)-Epothilone A is a Tubulin inhibitor. Potential mode of action/Key words: Targeting Tubulin, Tubulin polymerisation, Cytotoxic, Antibiotic
Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...