(-)-Epothilone A

Article number:

5600017

CAS No.:

152044-53-6

Formula:

C26H39NO6S

Synonyms:

EpoA

Molecular weight:

493,66 g/mol

Epothilone A exhibits kinetics similar to paclitaxel by inducing tubulin polymerization in vitro and producing enhanced microtubule stability and bundling in cultured cells. In contrast to paclitaxel, Epothilone A exhibits a greater cytotoxicity against P-glycoprotein-expressing multidrug resistant cells (IC50= 20 nM for MDR CCRF-CEM/VBL100 cells).Epo A is cytotoxic to human T-24 bladder carcinoma cells (IC50 = 0.05 µM in vitro) but has poor pharmacological properties and is 2-fold less potent in stabilizing microtubules compared to epothilone B. (-)-Epothilone A is a microtubule stabilizing agent. (-)-Epothilone A is a Tubulin inhibitor.

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(-)-Epothilone A

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Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...

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