(-)-Epothilone A

Article number:

5600017

CAS No.:

152044-53-6

Formula:

C26H39NO6S

Chemical description:

(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

Synonyms:

EpoA

Molecular weight:

493,66 g/mol

Epothilone A exhibits kinetics similar to paclitaxel by inducing tubulin polymerization in vitro and producing enhanced microtubule stability and bundling in cultured cells. In contrast to paclitaxel, Epothilone A exhibits a greater cytotoxicity against P-glycoprotein-expressing multidrug resistant cells (IC50= 20 nM for MDR CCRF-CEM/VBL100 cells). Epo A is cytotoxic to human T-24 bladder carcinoma cells (IC50 = 0.05 µM in vitro) but has poor pharmacological properties and is 2-fold less potent in stabilizing microtubules compared to Epothilone B. (-)-Epothilone A is a microtubule stabilizing agent. (-)-Epothilone A is a Tubulin inhibitor. Potential mode of action/Key words: Targeting Tubulin, Tubulin polymerisation, Cytotoxic, Antibiotic

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(-)-Epothilone A

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Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...

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