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Epothilone B
Article number:
5600140
CAS No.:
152044-54-7
Formula:
C27H41NO6S
Chemical description:
(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
Synonyms:
Patupilone
Molecular weight:
507,68 g/mol
Microtubule stabilization agent that promotes tubulin polymerization and induces G2-M cell cycle arrest. Inhibits a variety of human cancer cell lines, including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent anticancer activity in numerous human tumor xenografts in vivo. Epothilone B is a Tubulin inhibitor. Potential mode of action/Key words: Targeting Tubulin, Tubulin inhibitor, Anticancer, Induces Apoptosis
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