Exatecan Mesylate

Article number:

5600112

CAS No.:

169869-90-3

Formula:

C25H26FN3O7S

Chemical description:

(10S,23S)-23-amino-10-ethyl-18-fluoro-10-hydroxy-19-methyl-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaene-5,9-dione;methanesulfonic acid

Synonyms:

DX8951f

Molecular weight:

531,55 g/mol

Exatecan Mesylate is a potent topoisomerase I inhibitor, with an IC50 of 0.975 µg/mL. It significantly inhibits the proliferation of several cancer cell lines, with mean GI50s of 2.02 ng/mL, 2.92 ng/mL, 1.53 ng/mL, and 0.877 ng/mL for breast cancer cells, colon cancer cells, stomach cancer cells and lung cancer cells, respectively. Exatecan Mesylate also known as DX-8951f displays cytotoxic activities against PC-6, PC-6/SN2-5 cells, with mean GI50s of 0.186 and 0.395 ng/mL, respctively. Potential mode of action/Key words. Targeting DNA, Topoisomerase I inhibitor

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Exatecan Mesylate