Gefitinib, free base

Article number:

5500285

CAS No.:

184475-35-2

Formula:

C22H24ClFN4O3

Molecular weight:

446,90 g/mol

Gefitinib is a tyrosine kinase inhibitor that binds to the ATP-binding site of the enzyme. It has been shown that a mutation in the EGFR tyrosine kinase domain is responsible for activating anti-apoptotic pathways in gefinitib-sensitive non-small cell lung cancer.

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Gefitinib, free base

Protein Kinase Inhibitors

Protein kinases are enzymes that transfer phosphate groups from high-energy donors (typically nucleoside triphosphates) to surface exposed Serine, Threonine or Tyrosine side chains of other proteins and thus alter their ...

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