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Gefitinib, free base
Gefitinib is a tyrosine kinase inhibitor that binds to the ATP-binding site of the enzyme. It has been shown that a mutation in the EGFR tyrosine kinase domain is responsible for activating anti-apoptotic pathways in gefinitib-sensitive non-small cell lung cancer.
Protein Kinase Inhibitors
Protein kinases are enzymes that transfer phosphate groups from high-energy donors (typically nucleoside triphosphates) to surface exposed Serine, Threonine or Tyrosine side chains of other proteins and thus alter their ...