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Glucopiericidin A
Article number:
5500649
CAS No.:
108073-65-0
Formula:
C31H47NO9
Synonyms:
2,3-dimethoxy-5-methyl-6-[(2E,5E,7E,9R,10R,11E)-3,7,9,11-tetramethyl-10-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxytrideca-2,5,7,11-tetraenyl]-1H-pyridin-4-one
Molecular weight:
577,71 g/mol
Glucopiericidin A is a natural bioactive compound. Glucopiericidin A (GPA) interestingly alone did not inhibit filopodia protrusion, but synergistically inhibit protrusion with the mitochondrial respiration inhibitor, piericidin A (PA). These results suggested that GPA might inhibit glycolysis. GPA may therefore serve as a glucose transporter chemical probe. Simultaneous inhibition of both glycolysis and mitochondrial respiration dramatically decreased intracellular ATP levels, indicating that GPA inhibits ATP-dependent filopodia protrusion with PA. HCT-116: IC50=1,73 µM; PSN1 : IC50=>8,67 µM; T98G : IC50=>8,67 µM; A549 : IC50=0,87 µM (preliminary laboratory results). Journal of Antibiotics (1989), 42, 1734. Potential mode of action/Key words: Potential glycolysis inhibitor
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