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Glucopiericidin A is a natural bioactive compound. Glucopiericidin A (GPA) interestingly alone did not inhibit filopodia protrusion, but synergistically inhibit protrusion with the mitochondrial respiration inhibitor, piericidin A (PA). These results suggested that GPA might inhibit glycolysis. GPA may therefore serve as a glucose transporter chemical probe. Simultaneous inhibition of both glycolysis and mitochondrial respiration dramatically decreased intracellular ATP levels, indicating that GPA inhibits ATP-dependent filopodia protrusion with PA. HCT-116: IC50=1,73 uM; PSN1 : IC50=>8,67 uM; T98G : IC50=>8,67 uM; A549 : IC50=0,87 uM (preliminary laboratory results). Journal of Antibiotics (1989), 42, 1734.
What does fermentation mean? Fermentation (from latin fermentare) is generally defined as a conversion of material under aerobic or anaerobic conditions influenced by micro-organisms. "Micro-organism" is a collective term for usually ...