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Article number:
5500160
CAS No.:
83329-73-1
Formula:
C38H58O11
Chemical description:
[(2R,4R,5S,6R)-6-ethyl-2-hydroxy-2-[(2S,3R,4S)-3-hydroxy-4-[(2R,3S,4E,6E,9S,10S,11R,12E,14E)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyloxan-4-yl] (E)-4-amino-4-oxobut-2-enoate
Molecular weight:
690,86 g/mol
Hygrolidin is a macrocyclic lactone closely related to the group of bafilomycins. Hygrolidin is active against Valsa ceratosperma, the pathogen of an apple desease called "canker disease". Hygrolidin is active against SV40 tumour cells, and inhibits the growth of solid tumour-derived cell lines.HCT-116: IC50=0,0014 µM; PSN1 : IC50=0,72 µM; T98G : IC50=1,447 µM; A549 : IC50=1,447 µM (preliminary laboratory results). Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases. Hygrolidin has antitumor activity. Potential mode of action/Key words: Cell cycle arrest, Growth inhibitor, Antibiotic, Antitumoral
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