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IUPAC: (5S,10R)-7,9-dibrom-N-[(2R)-3-[2,6-dibrom-4-[2-[[[(5S,10R)-7,9-dibrom-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]-deca-2,6,8-trien-3-yl]carbonyl]amino]-1-hydroxyethyl] phenoxy]-2-hydroxypropyl]-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6
Isofistularin-3 is a natural, marine alkaloid belonging to the group of bromotyrosine-derivatives. It is a cytotoxic isoxazoline compound. Isofistularin-3 shows in vitro activity against HeLa cells. It has shown antiproliferative activities against Jurkat and U937 cellts (MTT-Assay). Isofistularin-3, as a DNA demethylating agent, induces cell cycle arrest and sensitization to TRAIL in cancer cells. Potential mode of action/Key words: Targeting DNA, Cell cycle arrest inducer, Cytotoxic
Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...