OH O O O HO OH O

LL-Z-1640-2

Article number:

5501038

CAS No.:

66018-38-0

Formula:

C19H22O7

Chemical description:

(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione

Synonyms:

5Z-7-Oxozeaenol

Molecular weight:

362,37 g/mol

LL-Z-1640-2 is a resocrcylic lactone of fungal origin that acts as a pontent and selective transforming growth factor-ß-activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC50=8 nM). Inhibits production of inflammatory mediators, and sensitztes cells to TRAIL- and TNF-Alpha-induced apoptosis in vitro.

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LL-Z-1640-2

Fermentation Products

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