Monomethyl auristatin F, free base

Article number:


CAS No.:




Chemical description:

[(2S,3S)-3-[[(2S)-2-[[(2R,4R)-2,4-dimethyloctanoyl]-methylamino]-4-methylpentanoyl]amino]-4-[methyl-[(2S)-3-methyl-1-[(2S)-2-[(2S)-2-methyl-5-oxo-2H-pyrrole-1-carbonyl]pyrrolidin-1-yl]-1-oxobutan-2-yl]amino]-4-oxobutan-2-yl] acetate


microcolin B; MMAF

Molecular weight:

731,96 g/mol

Monomethyl auristatin F (MMAF) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. It is linked to an antibody with high affinity to structures on cancer cells, causing MMAF to accumulate in such cells. MMAF is a Tubulin inhibitor. Mode of action: prevent tubulin polymerization. Potential mode of action/Key words: Targeting Tubulin, Antimitotic, Anticancer

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Monomethyl auristatin F, free base


Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...

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