Monomethyl auristatin F methyl ester, free base

Article number:

5600019

CAS No.:

863971-12-4

Formula:

C40H67N5O8

Chemical description:

L-Phenylalanine, N-methyl-L-valyl-Lvalyl-(3R,4S,5S)-3methoxy-5-pyrrolidinepropanoyl-, methyl ester

Synonyms:

MMAF-OMe; L-Phenylalanine, N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(aR,ßR,2S)-ß-methoxy-a-methyl-2-pyrrolidinepropanoyl-

Molecular weight:

745,99 g/mol

MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin. MMAF-Ome inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively. Potential mode of action/Key words: Targeting Tubulin, Cytotoxic, Anitumoral

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Monomethyl auristatin F methyl ester, free base

ADCs

Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...

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