Oleandrin

Article number:

5600067

CAS No.:

465-16-7

Formula:

C32H48O9

Chemical description:

acetic acid [(3S,5R,10S,13R,14S,16S,17'R)-14-hydroxy-3-[[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyl-2-tetrahydropyranyl]oxy]-10,13-dimethyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-16-yl] ester

Synonyms:

Cardenolide

Molecular weight:

576,73 g/mol

Oleandrin is a cardiac glycoside, used in the treatment of congestive heart failure and arrhythmia. Current trend shows use of some cardiac glycosides in the treatment of proliferative diseases, which includes cancer. Oleandrin (PBI-05204) inhibits the Na+, K+-ATPase activity with an IC50 of 620 nM. Potential mode of action/Key words: Apoptosis inducer, Potential Anticancer, Na+, K+-ATPase inhibitor

Plant: Oleander (Nerium oleander).

  • Is a toxic cardiac glycoside
  • oral ingestion of oleander may cause gastrointestinal and cardiac symptoms –> astrointestinal symptoms may include nausea and vomiting, excess salivation, abdominal pain and diarrhea
  • Cardiac complaints may include irregular pulse and rapid palpitations,
  • Extremities become poorly perfused and pale and cold.
  • Symptoms of poisoning can also affect the central nervous system, include drowsiness, tremors or muscle tremors until collapse with coma –> can lead to death

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Oleandrin

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Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...

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