Article number:


CAS No.:




Chemical description:

acetic acid [(3S,5R,10S,13R,14S,16S,17'R)-14-hydroxy-3-[[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyl-2-tetrahydropyranyl]oxy]-10,13-dimethyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-16-yl] ester



Molecular weight:

576,73 g/mol

Oleandrin is a cardiac glycoside, used in the treatment of congestive heart failure and arrhythmia. Current trend shows use of some cardiac glycosides in the treatment of proliferative diseases, which includes cancer. Oleandrin (PBI-05204) inhibits the Na+, K+-ATPase activity with an IC50 of 620 nM. Potential mode of action/Key words: Apoptosis inducer, Potential Anticancer, Na+, K+-ATPase inhibitor

Plant: Oleander (Nerium oleander).

  • Is a toxic cardiac glycoside
  • oral ingestion of oleander may cause gastrointestinal and cardiac symptoms –> astrointestinal symptoms may include nausea and vomiting, excess salivation, abdominal pain and diarrhea
  • Cardiac complaints may include irregular pulse and rapid palpitations,
  • Extremities become poorly perfused and pale and cold.
  • Symptoms of poisoning can also affect the central nervous system, include drowsiness, tremors or muscle tremors until collapse with coma –> can lead to death

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