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Oligomycin B is a macrolide antibiotic that inhibits membrane bound mitochondrial ATPase and which is practically free of homologs. Oligomycin B inhibits the growth of Rhodotorula gultinis, Aspergillus niger and other moulds. Origin: Streptomyces diastatochromogenes. HCT-116: IC50=0,0012 µM; PSN1 : IC50=1,24 µM; T98G : IC50=6,21 µM; A549 : IC50=6,21 µM (preliminary laboratory results). It is used as an eukaryotic ATP Synthase inhibitor, induces Apoptosis. Potential mode of action/Key words: Antibiotic, ATP Synthase inhibitor, Apoptosis inducer
Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...
Selman Waksman defined the term antibiotic in 1942 to describe any substance produced by a microorganism that is antagonistic to the growth of other microorganisms in high dilution. While this ...