O O O O O O O HO HO HO OH OH H H H

Oligomycin B

Article number:

5500652

CAS No.:

11050-94-5

Formula:

C45H72O12

Chemical description:

(1S,4E,5'R,6R,6'R,7S,8R,10S,11S,12R,14S,15R,16S,18E,20E,22S,25R,27R,28R,29S)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2S)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-oxane]-3,3',9,13-t

Molecular weight:

805,05 g/mol

Oligomycin B is a macrolide antibiotic that inhibits membrane bound mitochondrial ATPase and which is practically free of homologs. Oligomycin B inhibits the growth of Rhodotorula gultinis, Aspergillus niger and other moulds. Origin: Streptomyces diastatochromogenes. HCT-116: IC50=0,0012 µM; PSN1 : IC50=1,24 µM; T98G : IC50=6,21 µM; A549 : IC50=6,21 µM (preliminary laboratory results). It is used as an eukaryotic ATP Synthase inhibitor, induces Apoptosis. Potential mode of action/Key words: Antibiotic, ATP Synthase inhibitor, Apoptosis inducer

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Oligomycin B

ADCs

Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...

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Antibiotics

Selman Waksman defined the term antibiotic in 1942 to describe any substance produced by a microorganism that is antagonistic to the growth of other microorganisms in high dilution. While this ...

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