OH O O O

Pironetin

Article number:

5600144

CAS No.:

151519-02-7

Formula:

C19H32O4

Synonyms:

Pironetin A

Molecular weight:

324,45 g/mol

Pironetin is a potent inhibitor of alpha-tubulin. Pironetin covalently binds tubulin. Systematic alanine scanning shows, that the pironetin binding site was determined to be Lys352 of alpha-tubulin. Lys352 is located at the entrance of a small pocket of alpha-tubulin, and this pocket faces the beta-tubulin of the next dimer. This is the first compound that covalently binds to the alpha subunit of tubulin and Lys352 of alpha-tubulin and inhibits the interaction of tubulin heterodimers. HCT-116: IC50=0,002 uM; PSN1 : IC50=0,003 uM; T98G : IC50=15,43 uM; A549 : IC50=0,002 uM (preliminary laboratory results). Journal of Antibiotics (1996), 49, 173-180.

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Pironetin

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