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Article number:
5600144
CAS No.:
151519-02-7
Formula:
C19H32O4
Chemical description:
(2R,3R)-3-ethyl-2-[(E,2R,3S,4R,5S)-2-hydroxy-4-methoxy-3,5-dimethylnon-7-enyl]-2,3-dihydropyran-6-one
Synonyms:
Pironetin A
Molecular weight:
324,45 g/mol
Pironetin is a potent inhibitor of alpha-tubulin. Pironetin covalently binds tubulin. Systematic alanine scanning shows, that the pironetin binding site was determined to be Lys352 of alpha-tubulin. Lys352 is located at the entrance of a small pocket of alpha-tubulin, and this pocket faces the beta-tubulin of the next dimer. This is the first compound that covalently binds to the alpha subunit of tubulin and Lys352 of alpha-tubulin and inhibits the interaction of tubulin heterodimers. HCT-116: IC50=0,002 µM; PSN1 : IC50=0,003 µM; T98G : IC50=15,43 µM; A549 : IC50=0,002 µM (preliminary laboratory results). Journal of Antibiotics (1996), 49, 173-180. Potential mode of action/Key words: Targeting Tubulin, Alpha-Tubulin inhibitor, Antitumoral
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