N N N N N N NH HN HN H N N N N H N H O O O O O O O O O O O O HO OH

Quinaldopeptin

Article number:

5500655

CAS No.:

130743-07-6

Formula:

C62H78N14O14

Synonyms:

Antibiotic BMY 28662; Antibiotic BU 3845T

Molecular weight:

1243,40 g/mol

Quinaldopeptin is a quinomycin antibiotic isolated from an Amycolatopsis sp. with strong antimicrobial and cytotoxic activity. The symmetric cyclic peptide structure of Quinaldopeptin contains two intercalating naphtyl moieties which produce a bis-intercalation of DNA base pairs, creating DNA crosslinks and disturbing natural DNA processes. Quinaldopeptin is demonstrated to have high efficacy against gram-positive bacteria and cultured B16 melanoma cells. Quinaldopeptin is related to sandramycin and luzopeptins.

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Quinaldopeptin

Fermentation Products

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