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Article number:
5500655
CAS No.:
130743-07-6
Formula:
C62H78N14O14
Chemical description:
3-hydroxy-N-[(3S,4R,20S,28R)-27-[(3-hydroxyquinoline-2-carbonyl)amino]-4,15,28,39-tetramethyl-2,6,13,16,19,26,30,37,40,43-decaoxo-1,5,12,15,18,25,29,36,39,42-decazapentacyclo[42.4.0.07,12.020,25.031,36]octatetracontan-3-yl]quinoline-2-carboxamide
Synonyms:
Antibiotic BMY 28662; Antibiotic BU 3845T
Molecular weight:
1243,40 g/mol
Quinaldopeptin is a quinomycin antibiotic isolated from an Amycolatopsis sp. with strong antimicrobial and cytotoxic activity. The symmetric cyclic peptide structure of Quinaldopeptin contains two intercalating naphtyl moieties which produce a bis-intercalation of DNA base pairs, creating DNA crosslinks and disturbing natural DNA processes. Quinaldopeptin is demonstrated to have high efficacy against gram-positive bacteria and cultured B16 melanoma cells. Quinaldopeptin is related to sandramycin and luzopeptins. Potential mode of action/Key words: Targeting DNA, DNA crosslinking, Antibiotic, Cytotoxic
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