(S)-N-Deacetyl Colchicine

Article number:


CAS No.:





(7S)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxy-benzo[a]heptalen-9(5H)-one; (-)-7-Deacetylcolchicine; NSC 201400;

Molecular weight:

357,40 g/mol

(S)-N-Deacetyl Colchicine is an antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. It stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway. References: Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998), Alali, F., et al.: Phytochem. Anal., 19, 385 (2008), Chang, D., et al.: Bioorg. Med. Chem. Lett., 19, 4416 (2009). Potential mode of action/Key words: Targeting Tubulin, Antimitotic, Induces Apoptosis

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(S)-N-Deacetyl Colchicine


Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...

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