Senkirkine

Article number:

7500441

CAS No.:

2318-18-5

Formula:

C19H27NO6

Chemical description:

(4E,6R,7R,11Z)-4-ethylidene-7-hydroxy-6,7,14-trimethyl-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione

Synonyms:

Renardine

Molecular weight:

365,42 g/mol

Senkirkine is a pyrrolizidine alkaloid isolated from Tussilago farfara. Pyrrolizidine alkaloids are secondary metabolites, produced by several plant species as protection against insect herbivores. Approximately 6000 plant species worldwide may contain pyrrolizidine alkaloids. They are mainly found in the families of the Boraginaceae, Asteraceae and Fabaceae. The PA-content depends on several factors (species, plant organ, harvest, storage, extraction procedures). Contents vary from trace amounts up to 19 % based on dry weight. These alkaloids occur in two forms, as tertiary base PAs and their N-oxide (PANO). They are common food contaminants in herbs, tea, salad, leafy vegetables and honey. Feed can be contaminated so that the plant products find their way in the food chain indirectly also over meat, milk and eggs. Pyrrolizidine alkaloids have adverse health effects and were classified as genotoxic, carcinogen and hepatotoxic. [Reference: EFSA Journal 2011;9(11):2406 [134 pp.]. doi:10.2903/j.efsa. 2011.2406]

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Article number: 7501771
CAS No.: 548-90-3
Formula: C18H27NO6
Molecular weight: 353,41 g/mol

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Senkirkine

Pyrrolizidine alkaloids

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With more than 1200 substances (reference substances) Cfm Oskar Tropitzsch GmbH offers a broad range of herbal reference standards for the natural products chemistry. The portfolio consists substances from all ...

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