Swainsonine

Article number:

5500494

CAS No.:

72741-87-8

Formula:

C8H15NO3

Chemical description:

(1S,2R,8R,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizine-1,2,8-triol

Synonyms:

Tridolgosir; (1S,2R,8R,8aR)-1,2,8-Trihydroxyindolizidin

Molecular weight:

173,21 g/mol

Swainsonine is described as an potent inhibitor of various a-mannosidase, especially of alpha-mannosidase II. Swainsonine inhibits glycoprotein processing and acts as well as immune modulator.Swainsonine is an indolizidine alkaloid from the plant Metarrhizium anisopliae that is used as a potent alpha-mannosidase inhibitor. It has a potential for treating cancers such as glioma and gastric carcinoma. However, a phase II clinical trial of GD0039 (a hydrochloride salt of swainsonine) in patients with renal carcinoma was discouraging. Swainsonine's activity against tumors is attributed to its stimulation of macrophages. Swainsonine also has potential uses as an adjuvant for anti-cancer drugs and other therapies in use. In mice, swainsonine reduces the toxicity of doxorubicin, suggesting that swainsonine might enable use of higher doses of doxorubicin. Swainsonine may promote restoration of bone marrow damaged by some types of cancer treatments. Origin: From Metharhizium anisopliae. Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible a-mannosidase inhibitor. Swainsonine induces Apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity. Potential mode of action/Key words: Alpha-mannosidase inhibitor, Apoptosis inducer, Antitumoral

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Swainsonine

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