Tamapin

Article number:

5250060

Chemical description:

Sequence: [Cys3-Cys21; Cys8-Cys26; Cys12-Cys28]; Ala-Phe-Cys3-Asn-Leu-Arg-Arg-Cys8-Glu-Leu-Ser-Cys12-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys21

Molecular weight:

3459,00 g/mol

Tamapin is a peptide toxin isolated from the venom of the Indian red scorpion Mesobuthus Tamulus. Tamapin is amidated at its C-terminal tyrosine residue (contrary to recombinant tamapin, Smartox’ tamapin is amidated). It binds to small conductance Ca2+-activated K+ channels (SK channels) with high affinity and inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus as well as in cell lines expressing distinct SK channel subunits. Tamapin is an excellent toxin to discriminate among SK channel subtypes because it presents different affinities for SK1 (42 nM), SK2 (24 pM) and SK3 (1.7 nM) channels. This toxin is also the most potent SK2 channel blocker characterized so far (IC50 for SK2 channels = 24 pM).

Inform about
Tamapin

Synthetic Toxins

What are toxins? As is well-known, toxins occur in a large number of animal species. Among the long list of toxins, we would like to mention apamin, the toxin of the ...

Read more

Toxins

Natural Toxins, synthetically produced

What are toxins? As is well-known, toxins occur in a large number of animal species. Among the long list of toxins, we would like to mention apamin, the ...

Read more