Thiocoraline

Article number:

5500262

CAS No.:

173046-02-1

Formula:

C48H56N10O12S6

Chemical description:

3-hydroxy-N-[(1S,7R,11R,14S,20R,24R)-20-[(3-hydroxyquinoline-2-carbonyl)amino]-2,12,15,25-tetramethyl-11,24-bis(methylsulfanylmethyl)-3,6,10,13,16,19,23,26-octaoxo-9,22,28,29-tetrathia-2,5,12,15,18,25-hexazabicyclo[12.12.4]triacontan-7-yl]quinoline-2

Molecular weight:

1157,41 g/mol

Thiocoraline is an DNA polymerase inhibitor. The source of this compound is Micromonospora marina, an Actinomycete bacteria. Thiocoraline indues profound perturbations of the cell cycle. Thiocoraline does not inhibit DNA-topoisomerase II enzymes in vitro, nor does it induce DNA breakage in cells exposed to effective drug concentrations. Inhibition of DNA polymerase alpha-activity. Potential mode of action/Key words: Targeting DNA, DNA-Polymerase inhibitor

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Thiocoraline

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