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Tripolin A is described as an specific non-ATP competitve Aurora A kinase inhibitor. Tripolin A doesn`t significantly inhibit Aurora B kinase in mammalian cells. Tripolin A reduces localization of Aurora A on spindle microtubules, affects centrosome integrity, spindle formation and lenght and MT dynamitcs in interphase. Tripolin A is a novel small molecule inhibitor of Aaurora A kinase. Potential mode of action/Key words: Targeting Tubulin, Aurora A kinase inhibitor,
Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...