N H N N O O O O S N N H O O COOH OH O

Tubulysin A

Article number:

5600146

CAS No.:

205304-86-5

Formula:

C43H65N5O10S

Chemical description:

IUPAC: (2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-5-(4-hydroxyphenyl)-2-methylpentanoic acid

Molecular weight:

844,07 g/mol

Tubulysins show a very high cytotoxic activity against in vitro and in vivo tumor models, especially against resistant tumor cell lines. Many representatives of these natural products are several orders of magnitude more potent than other available chemotheraprutics. Based on the SAR of the tubulysins this class allows for many chemical conjugation and targeting strategies which offer several different development opportunities. Potential mode of action/Key words: Targeting Tubulin, Tubulin polymerization inhibitor, Cytotoxic, Induces Apoptosis, Anticancer

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Tubulysin A

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