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Article number:
5500528
CAS No.:
889640-30-6
Formula:
C30H28N6O6S4
Chemical description:
2-hydroxy-3-(2-hydroxy-14,18-dimethyl-13,17-dioxo-15,16-dithia-10,12,18-triazapentacyclo[12.2.2.01,12.03,11.04,9]octadeca-4,6,8-trien-3-yl)-14,18-dimethyl-15,16-dithia-10,12,18-triazapentacyclo[12.2.2.01,12.03,11.04,9]octadeca-4,6,8-triene-13,17-dion
Molecular weight:
696,84 g/mol
Verticillin A is a fungal epipolythiodioxopiperazine (ETP) metabolite with antibiotic properties. Verticillin A is inactive against fungi, Verticillin A showed considerable anti-tumor properties against HeLa Cells. Verticillin A is a selective HMTase inhibitor. Verticillin A selectively inhibits SUV39H1, SUV39H2, G9a, and GLP in vitro. Verticillin A is structurally very similar to Chaetocin, differing only in the position of two hydroxyl groups.The potential mode of action is connected to the chromatin remodeling. Potential mode of action/Key words: Targeting DNA, HMTase inhibitor, Antibiotic, Antitumoral
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