Asiaticoside – appealing for cosmetic and pharma
Research is focusing on its pharmacological properties: anti-depression, anti-inflammatory and anti-tumor. Recently revealed activities are the protection of nerve cells, inhibition of apoptosis of neural cells and improvement of memory.
Sun et al showed the nerve protective effect of Asiaticoside in an ischemia-hypoxia cell model in vitro. Asiaticoside reduced the lactate dehydrogenase level and also could regulate the expression of apoptotic factors, like bcl-2, Bax and caspase-3. The authors suggest it will play a greater role in stroke treatment, with broad prospects for development.
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- Sampath U, Janardhanam VA. Asiaticoside, a trisaccaride triterpene induces biochemical and molecular variations in brain of mice with parkinsonism. Transl Neurodegener. 2013;2:23.
- Mook-Jung I, Shin JE, Yun SH, Huh K, Koh JY, Park HK, Jew SS, Jung MW. Protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity. J Neurosci Res. 1999;58:417–25.
- Sun T1, Liu B1, Li P1. Nerve Protective Effect of Asiaticoside against Ischemia-Hypoxia in Cultured Rat Cortex Neurons. Med Sci Monit. 2015 Oct 8;21:3036-41. doi: 10.12659/MSM.894024.