Asiaticoside – appealing for cosmetic and pharma
Research is focusing on its pharmacological properties: anti-depression, anti-inflammatory and anti-tumor. Recently revealed activities are the protection of nerve cells, inhibition of apoptosis of neural cells and improvement of memory. Sun et al showed the nerve protective effect of Asiaticoside in an ischemia-hypoxia cell model in vitro. Asiaticoside reduced the lactate dehydrogenase level and also […]
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PhenoFrag – ADC-latest news
To analyze all these effects and interactions is impossible without a valid, fast and reliable system. If you have new ideas for Payloads, APIs, try our PhenoFrag to generate the data which provides you with the answers you need to speed up your drug development.Interested? Please just get in touch with us. PhenoFrag: Develops novel, safe […]
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Astragalus membranaceus and its Astragalosides
Of two recently published studies, one is focusing on the effect of Astragalus membranaceus on colorectal cancer. The antitumor effect was assessed on subcutaneous tumors of human colorectal cancer cell line grafted into nude mice. The profiling of the microarray expression of the tumors showed its potential as a therapeutic drug. Another publication discusses the […]
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Finding the best solution for you! …but what’s behind this phrase?
First of all you define the specifications and quality requirements which you need – not what might be available. The customer – so just you – defines the quantity: from lab scale to commercial scale. Securing supply: projects start always with small quantity requirements and increasing demand for material and documentation throughout the lifecycle of […]
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28. Irseer Naturstofftage
24 – 26 February 2016 Kloster Irsee, Germany We participate, as in the previous years at the 28th “Irseer Naturstofftage” which are taking place at Kloster Irsee. Natural products are of great importance for basic research as well as for research and development in the pharmaceutical and agrochemical industries. The annual meeting in Irrsee provides a […]
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World adc Berlin 2016
February 8th – 10th, 2016 Berlin, Germany Let`s meet and brainstorm…. Event topics are i.e.: – Discover ADC Payloads with Differentiated Mechanisms of Action – Effectively Translate into the Clinic – Advance Clinical Scale Manufacturing Find novel molecules as payloads and improve your research! We are looking […]
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Christmas Greetings from Marktredwitz
Merry Christmas from Cfm Oskar Tropitzsch GmbH The Cfm Oskar Tropitzsch team thanks you for the good and amicable cooperation in the ending Year 2015. On the picture you see the “living room” of Marktredwitz, the city center. In 2016 Marktredwitz celebrates “200 Years in Bavaria” – another reason to visit us – in the […]
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Drug Development – 7. Cooperation Forum
The forum offers people from industry and science to get in contact and access to topic information regarding the following key aspects: Antibiotic therapy and resistance Development of new antiinfektiva Libraries of active ingredients Nucleotide-based therapeutic and vaccination Sepsis diagnosis Mobile lab to fight against Ebola
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Paeonol – an actor against cancer related inflammation (CRI)
In mouse melanoma cells paeonol had an effect on cell proliferation, apoptosis and the secretion of proinflammatory cytokines, like TNF-α, IL-1β, IL-6 and TGF-β. In vivo the results showed an attenuation of lung metastases accompanied by a downregulation of proinflammatory cytokines in the serum. The authors indicate that the anti-tumor activity of this compound is […]
Read moreBeta-Amanitin – a potential payload for antibody drug conjugates (ADCs)
beta-Amanitin is an inhibitor of eukaryotic RNA polymerase II and RNA polymerase III, but not RNA polymerase I or bacterial RNA polymerase. It inhibits mammalian protein synthesis. These properties make it interesting as a new potential drug for ADC research. α-Amanitin is already known as effective payload for ADCs. beta-Amanitin has a comparable biological activity […]
Read moreFunctional Ingredients
Cooperation forum Functional Ingredients November 25th 2015, Bayreuth Ingredients such as plant metabolites and proteins can have health-beneficial, nurturing or preserving properties and add value to food and cosmetic products. Novel processes allow their application in food packaging materials and textiles for sanitary products. These functionalized materials offer new oxygen barrier characteristics or antimicrobial properties. The Forum allows you to get direct contact […]
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Zinc oxide
Hatamie A et al. showed that a ZnO-based textile has photocatalytic and antibacterial activities. In addition the textile exhibited a promising sensing response. The modified textile was created by direct in situ growth of vertically aligned one-dimensional ZnO NRs onto textile surfaces. The effects provided by ZnO are a new approach to create smart textiles: […]
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