Product of the Month August: Everolimus
Everolimus is a synthetic derivative of the natural compound Sirolimus (Rapamycin), originally isolated from the bacterium Streptomyces hygroscopicus found on Easter Island (Rapa Nui).
As a member of the macrolide class and mTOR inhibitors, Everolimus boasts a remarkable range of applications. From transplant medicine to cancer research and laboratory technology.
Everolimus was developed to optimize the pharmacological properties of Sirolimus (Rapamycin). It features a complex macrocyclic lactone structure and exerts its effects by inhibiting the protein mTOR (mammalian Target of Rapamycin).
Use as a Laboratory Chemical
In preclinical research and cell biology experiments, Everolimus is a valuable tool for investigating signal transduction pathways, particularly the mTOR signaling pathway. It is used:
• to inhibit cell proliferation in cell culture models
• to modulate immune responses in immunological studies
• to analyze tumor biology, especially in mTOR-dependent cancers
• as a control substance in drug screenings and comparative studies
Thanks to its high specificity and well-documented mechanisms of action, Everolimus is ideally suited for in-vitro studies requiring targeted interventions in the cell cycle or protein synthesis.
Applications in the Pharmaceutical Field
Beyond its role in the lab, Everolimus has a wide range of pharmaceutical and medical applications:
1. Immunosuppression in Transplantation
• Kidney and heart transplants: Prevents graft rejection by inhibiting T-cell proliferation
2. Oncology
• Hormone receptor-positive breast cancer
• Neuroendocrine tumors (NETs)
• Renal cell carcinoma
Everolimus helps slow tumor growth in these contexts.
3. Other Applications
• Tuberous sclerosis: Treatment of subependymal giant cell astrocytomas and renal angiomyolipomas
• Polycystic kidney disease: Used in studies to inhibit cyst growth
Everolimus offers exciting opportunities for chemists and lab technicians to explore cellular mechanisms, while the pharmaceutical industry is already benefiting from its therapeutic potential.
Available in GMP Quality and for Research Use
Do you have questions about Everolimus or Sirolimus (Rapamycin)?
Our expert Michael Schäffler will be happy to assist you. Feel free to contact him via email: michael.schaeffler@cfmot.de
We source Everolimus in GMP and research-grade quality from our long-standing European partner.
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