alpha-Amanitin – fungal fermentation origin

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Chemical description:


Molecular weight:

918,97 g/mol

alpha-Amanitin, a bicyclic octapeptide, belongs originally to the large group of the so called amatoxins.The source of our specific alpha-Amanitin is fungal fermentation. By this production method the supply problems are solved. alpha-Amanitin is an inhibitor of RNA polymerase II (0.02 micrograms/ml). RNA polymerase I was also inhibited by the relatively high concentration of alpha-Amanitin (IC50 = 100 micrograms/ml and IC70 = 750 micrograms/ml). The toxin works by binding to the bridging helix of RNA polymerase II inhibiting the translocation of RNA and DNA needed to empty the site for the next synthesis run. The transcription rated is lowed down by the factor of 1,000. Potential mode of action/Key words: Targeting RNA, RNA-Polymerase 1 & 2 inhibitor

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alpha-Amanitin – fungal fermentation origin


Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...

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