alpha-Amanitin – Fermentations Ursprung



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918,97 g/mol

alpha-Amanitin, a bicyclic octapeptide, belongs originally to the large group of the so called amatoxins.The source of our specific alpha-Amanitin is fungal fermentation. By this production method the supply problems are solved. alpha-Amanitin is an inhibitor of RNA polymerase II (0.02 micrograms/ml). RNA polymerase I was also inhibited by the relatively high concentration of alpha-Amanitin (IC50 = 100 micrograms/ml and IC70 = 750 micrograms/ml). The toxin works by binding to the bridging helix of RNA polymerase II inhibiting the translocation of RNA and DNA needed to empty the site for the next synthesis run. The transcription rated is lowed down by the factor of 1,000. Potential mode of action/Key words: Targeting RNA, RNA-Polymerase 1 & 2 inhibitor

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alpha-Amanitin – Fermentations Ursprung


Cfm Oskar Tropitzsch GmbH ist bekannt dafür, ausgefallene Forschungsreagenzien zu liefern – in diesem Falle Cytoxoxins für Antikörper. Bei diesen „Warheads“ handelt es sich um hoch toxische Substanzen, wie z.B. ...

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