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Article number:
5500642
CAS No.:
88899-55-2
Formula:
C35H58O9
Chemical description:
(3Z,5E,11E,13E)-16-[4-(2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl)-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
Synonyms:
NSC 381866
Molecular weight:
622,80 g/mol
Bafilomycin A1 is a inhibitor of V-ATPase in microoganisms, plant- and animal cells. Origin: Streptomyces griseus HCT-116: IC50=0,0002 µM; PSN1 : IC50=1,605 µM; T98G : IC50=8,026 µM; A549 : IC50=8,026 µM (preliminary laboratory results). International Journal of Oncology (2011), 38(3), 643-654. Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H+-ATPase (V-ATPase) with IC50 values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis. Potential mode of action/Key words: V-ATPase inhibitor, Antibiotic, Apoptosis inducer
Article number: 5501157
CAS No.: 88899-56-3
Formula: C44H65NO13
Molecular weight: 815,99 g/mol
Article number: 5501161
CAS No.: 88979-61-7
Formula: C39H60O12
Molecular weight: 720,89 g/mol
Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...
What does fermentation mean? Fermentation (from latin fermentare) is generally defined as a conversion of material under aerobic or anaerobic conditions influenced by micro-organisms. "Micro-organism" is a collective term for usually ...
Mycotoxins are secondary metabolites of molds fungis which have a very toxic effect on human being. The species of Mycotoxins subdivide to aflatoxins, fumonisines, ochratoxins and fusarium toxins. The name ...