for our newsletter!
Bafilomycin A1 is a inhibitor of V-ATPase in microoganisms, plant- and animal cells. Origin: Streptomyces griseus HCT-116: IC50=0,0002 µM; PSN1 : IC50=1,605 µM; T98G : IC50=8,026 µM; A549 : IC50=8,026 µM (preliminary laboratory results). International Journal of Oncology (2011), 38(3), 643-654. Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H+-ATPase (V-ATPase) with IC50 values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis. Potential mode of action/Key words: V-ATPase inhibitor, Antibiotic, Apoptosis inducer
Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...
What does fermentation mean? Fermentation (from latin fermentare) is generally defined as a conversion of material under aerobic or anaerobic conditions influenced by micro-organisms. "Micro-organism" is a collective term for usually ...
Mycotoxins are secondary metabolites of molds fungis which have a very toxic effect on human being. The species of Mycotoxins subdivide to aflatoxins, fumonisines, ochratoxins and fusarium toxins. The name ...