HOOC COOH CH 3 H 3 C CH 3 COOH OCH 3

Bongkrekic acid

Article number:

5500627

CAS No.:

11076-19-0

Formula:

C28H38O7

Chemical description:

IUPAC-Name: 20-Carboxymethyl-6-methoxy-2,5,17-timethyldocosa-2,4,8,10,14,18,20-heptaenedioic acid

Synonyms:

Bongkrek acid

Molecular weight:

486,60 g/mol

Bongkrekic acid is a toxin produced in fermented coconut contaminated by the cacterium Burkholderia gladioli pathovar cocovenenans. It is highly toxic because the compound inhibits the ADP/ATP translocase. Besides this it inhibits the Glutathione transferase inhibitor as well. Bongkrekic acid is a p potent inhibitory ligand of the mitochondrial adenine nucleotide translocase (ANT). It inhibits mitochondrial permeability transition pore opening. Delivery of bongkrekic acid to the mitochondria prevents apoptosis in HeLa cells.

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Bongkrekic acid