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Article number:
5500627
CAS No.:
11076-19-0
Formula:
C28H38O7
Chemical description:
IUPAC-Name: 20-Carboxymethyl-6-methoxy-2,5,17-timethyldocosa-2,4,8,10,14,18,20-heptaenedioic acid
Synonyms:
Bongkrek acid; Flavotoxin A
Molecular weight:
486,60 g/mol
Bongkrekic acid is a toxin produced in fermented coconut contaminated by the cacterium Burkholderia gladioli pathovar cocovenenans. It is highly toxic because the compound inhibits the ADP/ATP translocase. Besides this it inhibits the Glutathione transferase inhibitor as well. Bongkrekic acid is a p potent inhibitory ligand of the mitochondrial adenine nucleotide translocase (ANT). It inhibits mitochondrial permeability transition pore opening. Delivery of bongkrekic acid to the mitochondria prevents apoptosis in HeLa cells.
What does fermentation mean? Fermentation (from latin fermentare) is generally defined as a conversion of material under aerobic or anaerobic conditions influenced by micro-organisms. "Micro-organism" is a collective term for usually ...