Calicheamicin g1

Article number:


CAS No.:




Chemical description:

Carbamic acid, N-[(1R,4Z,8S,13E)-8-[[4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-a-Lmannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-ß-D-ribohexopyranosyl]oxy]amino]-2-O-[2,4-dideoxy-4-(ethylamino)-3-O-methyl-a-L-threo-pe


Calicheamicin; calicheamicin gamma(1); Calichemicin gamma1; 108212-75-5; CA006390; C11469

Molecular weight:

1368,35 g/mol

The group of calicheamicins is a class of enediyne anti-tumor antibiotics. They are derived from the bacterium Micromonospora echinospora.Calicheamicins are extremly toxic to all cells. Calicheamicins target the DNA and cause strand breaks. They bind with DNA in the minor groove, wherein they then undergo a cyclization reaction. CMC-544, constisting of a humanized CD22 Ab linked to calicheamicin, is effective in pediatric primary B-cell precursor acute lymphoblastic leikemia (BCP-ALL) cell lines in vitro. CMC-544 induces cell death in various ALL cell lines in a dose-and time-dependent way, with IC50 values ranging from 0.15 to 4.9 ng/ml. Potential mode of action/Key words: Targeting DNA, Strand break inducer, Antitumoral, Antibiotic

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Calicheamicin g1


Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...

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