Calicheamicin g1



CAS Nr.:




Chemische Beschreibung:

Carbamic acid, N-[(1R,4Z,8S,13E)-8-[[4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-a-Lmannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-ß-D-ribohexopyranosyl]oxy]amino]-2-O-[2,4-dideoxy-4-(ethylamino)-3-O-methyl-a-L-threo-pe


Calicheamicin; calicheamicin gamma(1); Calichemicin gamma1; 108212-75-5; CA006390; C11469


1368,35 g/mol

The group of calicheamicins is a class of enediyne anti-tumor antibiotics. They are derived from the bacterium Micromonospora echinospora.Calicheamicins are extremly toxic to all cells. Calicheamicins target the DNA and cause strand breaks. They bind with DNA in the minor groove, wherein they then undergo a cyclization reaction. CMC-544, constisting of a humanized CD22 Ab linked to calicheamicin, is effective in pediatric primary B-cell precursor acute lymphoblastic leikemia (BCP-ALL) cell lines in vitro. CMC-544 induces cell death in various ALL cell lines in a dose-and time-dependent way, with IC50 values ranging from 0.15 to 4.9 ng/ml. Potential mode of action/Key words: Targeting DNA, Strand break inducer, Antitumoral, Antibiotic

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Calicheamicin g1


Cfm Oskar Tropitzsch GmbH ist bekannt dafür, ausgefallene Forschungsreagenzien zu liefern – in diesem Falle Cytoxoxins für Antikörper. Bei diesen „Warheads“ handelt es sich um hoch toxische Substanzen, wie z.B. ...

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