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Cordycepin from Cordyceps militaris. Cordycepin blocks revovery of non-heat-shock mRNA translation following heat shock in Drosophilla. Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotide transferase-positive leukemic cells has been reported. Cordycepin blocks the Smad signaling by 3`-deoxyadenosine (a mechanism for its anti-fibriotic potential).
Selman Waksman defined the term antibiotic in 1942 to describe any substance produced by a microorganism that is antagonistic to the growth of other microorganisms in high dilution. While this ...