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Duocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM. It is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. The product demonstrates synergistic cytotoxicity against glioblastoma multiforme cells treated with proton radiation in vitro. Potential mode of action/Key words: Targeting DNA, DNA alkylator, Anticancer
Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...