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Article number:
5600181
CAS No.:
130288-24-3
Formula:
C25H23N3O7
Molecular weight:
477.47 g/mol
Duocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM. It is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. The product demonstrates synergistic cytotoxicity against glioblastoma multiforme cells treated with proton radiation in vitro. Potential mode of action/Key words: Targeting DNA, DNA alkylator, Anticancer