Duocarmycin SA

Duocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM. It is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. The product demonstrates synergistic cytotoxicity against glioblastoma multiforme cells treated with proton radiation in vitro. Potential mode of action/Key words: Targeting DNA, DNA alkylator, Anticancer