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Article number:
5600120
CAS No.:
863971-53-3
Formula:
C40H42N6O10
Chemical description:
9-Fluorenylmethyloxycarbonyl-valyl-citrullyl-(4-aminobenzyl)-(4-nitrophenyl)carbonate
Synonyms:
(9H-fluoren-9-yl)methyl (S)-3-methyl-1-((S)-1-(4-(((4-nitrophenoxy)carbonyloxy)methyl)phenylamino)-1-oxo-5-ureidopentan-2-ylamino)-1-oxobutan-2-ylcarbamate
Molecular weight:
766,81 g/mol
Linker for Antibody-Drug-Conjugation (ADC). The Val-Cit will specifically be cleaved by catepsin B. As this enzyme is only present in the lysosome the ACD payload will be release only in the cell. REFERENCES Laurent Ducry (ed.), Antibody-Drug Conju gates, Methods in Molecular Biology, vol. 1045, DOI 10.1007/978-1-62703-541-5_5, # Springer Science+Business Media, LLC 2013. Potential mode of action/Key words: Induces Apoptosis
Cfm Oskar Tropitzsch offers ecxept payloads also other important reagents for the Conjugation of ADCs. One example is Dithiothreitol (DTT, Clealand`s reagent). DTT is a redox reagent in molecular biology. DTT ...