Fmoc-Val-Cit-PAB-PNP

Article number:

5600120

CAS No.:

863971-53-3

Formula:

C40H42N6O10

Chemical description:

9-Fluorenylmethyloxycarbonyl-valyl-citrullyl-(4-aminobenzyl)-(4-nitrophenyl)carbonate // Synonyms: (9H-fluoren-9-yl)methyl (S)-3-methyl-1-((S)-1-(4-(((4-nitrophenoxy)carbonyloxy)methyl)phenylamino)-1-oxo-5-ureidopentan-2-ylamino)-1-oxobutan-2-ylcarbamate

Molecular weight:

766,8 g/mol

Linker for Antibody-Drug-Conjugation (ADC). The Val-Cit will specifically be cleaved by catepsin B. As this enzyme is only present in the lysosome the ACD payload will be release only in the cell. REFERENCESLaurent Ducry (ed.), Antibody-Drug Conju gates, Methods in Molecular Biology, vol. 1045, DOI 10.1007/978-1-62703-541-5_5, # Springer Science+Business Media, LLC 2013.

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Fmoc-Val-Cit-PAB-PNP

Reagents for ADCs

Cfm Oskar Tropitzsch offers ecxept payloads also other important reagents for the Conjugation of ADCs. One example is Dithiothreitol (DTT, Clealand`s reagent). DTT is a redox reagent in molecular biology. DTT ...

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