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Geldanamycin is a benzoquinone ansamycin antibiotic. Geldamycin is among other things used to cure cancer patients. It specifically ties up to the heat shock proteine HSP 90 (Heat Shock Protein 90) and changes its function. The bond of Geldamycin to HSP 90 causes the decomposition of target-proteins such as Tyrosinkinasen, Steroidrezeptoren, Transkriptionsfactors and cell-cycle regulative Kinasen. It induces the inactivation, destabilisation and finally the decomposition of HIF-1a. An extremely interesting research reagent for the biotechnology industry Origin: Streptomyces Hygroscopicus var Geldanus
Selman Waksman defined the term antibiotic in 1942 to describe any substance produced by a microorganism that is antagonistic to the growth of other microorganisms in high dilution. While this ...