Geldanamycin

Geldanamycin is a benzoquinone ansamycin antibiotic.Geldamycin has been used in clinical trials for cancer treatment. It specifically ties up to the heat shock proteine HSP 90 (Heat Shock Protein 90) and changes its function. The bond of Geldamycin to HSP 90 causes the decomposition of target-proteins such as Tyrosinkinasen, Steroidrezeptoren, Transkriptionsfactors and cell-cycle regulative Kinasen. It induces the inactivation, destabilisation and finally the decomposition of HIF-1a. An extremely interesting research reagent for the biotechnology industry. Origin: Streptomyces Hygroscopicus var Geldanus-References: 1. Fukuyo, Y. et al., Geldanamycin and its anti-cancer activities. Cancer Lett. 2010; 290(1):24-35. 2. Miyata, Y., Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents. Curr Pharm Des. 2005; 11(9):1131-8. Potential mode of action/Key words: Alters function of HSP 90, Antibiotic, Anticancer