Article number:


CAS No.:




Chemical description:


(2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one; Eriodictyol 4'-monomethyl ether; Hesperitin; 3',5,7-Trihydroxy 4'-methoxyflavanone

Molecular weight:

302,28 g/mol

The pleiotropic effects of fisetin and hesperetin on human acute promyelocytic leukemia cells are mediated through apoptosis, cell cycle arrest, and alterations in signaling networks. Adan A, Baran Y. Tumour Biol. 2015 Jun 17. [Epub ahead of print] *** Hesperetin Induces the Apoptosis of Gastric Cancer Cells via Activating Mitochondrial Pathway by Increasing Reactive Oxygen Species. Zhang J, Wu D, Vikash, Song J, Wang J, Yi J, Dong W. Dig Dis Sci. 2015 May 14. [Epub ahead of print] *** Hesperetin induces melanin production in adult human epidermal melanocytes. Usach I, Taléns-Visconti R, Magraner-Pardo L, Peris JE. Food Chem Toxicol. 2015 Jun;80:80-4. doi: 10.1016/j.fct.2015.02.017. Epub 2015 Mar 9. *** Hesperetin induces the apoptosis of hepatocellular carcinoma cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species, ATP and calcium. Zhang J, Song J, Wu D, Wang J, Dong W. Med Oncol. 2015 Apr;32(4):101. doi: 10.1007/s12032-015-0516-z. Epub 2015 Mar 4. *** Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases. Roohbakhsh A, Parhiz H, Soltani F, Rezaee R, Iranshahi M. Life Sci. 2015 Mar 1;124:64-74. doi: 10.1016/j.lfs.2014.12.030. Epub 2015 Jan 24. Review. *** Hesperetin Induces Apoptosis in Breast Carcinoma by Triggering Accumulation of ROS and Activation of ASK1/JNK Pathway. Palit S, Kar S, Sharma G, Das PK. J Cell Physiol. 2015 Aug;230(8):1729-39. doi: 10.1002/jcp.24818. *** Protective effect of hesperetin in rat model of partial sciatic nerve ligation induced painful neuropathic pain: an evidence of anti-inflammatory and anti-oxidative activity. Aswar M, Kute P, Mahajan S, Mahajan U, Nerurkar G, Aswar U. Pharmacol Biochem Behav. 2014 Sep;124:101-7. doi: 10.1016/j.pbb.2014.05.013. Epub 2014 May 25. *** Protective effect of hesperetin and naringenin against apoptosis in ischemia/reperfusion-induced retinal injury in rats. Kara S, Gencer B, Karaca T, Tufan HA, Arikan S, Ersan I, Karaboga I, Hanci V. ScientificWorldJournal. 2014 Jan 30;2014:797824. doi: 10.1155/2014/797824. eCollection 2014.

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Secondary Plant Ingredients

Secondary metabolites in plants are active plant ingredients, also called phytochemicals.. The demand for Phytochemicals is constantly growing not only for reference substances (for quality tests) , but for high purity ...

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