O OH O H 3 C O O CH 3 OH O OH

Hypothemycin

Article number:

5600141

CAS No.:

76958-67-3

Formula:

C19H22O8

Molecular weight:

378,37 g/mol

Exhibits antifungal and cytotoxic activity against some tumor cell lines partly attributed to inhibition of Ras-inducible genes. Inhibits proliferation of mouse and human T cells and modulates production of cytokines during T cell activation. Facilitates the ubiquitinylation process of cyclin D1. Has been identified as a potent and selective inhibitor of threonine/tyrosine-specific kinase, MEK, and other protein kinases that contain a conserved cysteine residue in the ATP-binding site in both in vitro and in vivo studies. HCT-116: IC50=0,0026 uM; PSN1 : IC50=0,26 uM; T98G : IC50=2,6 uM; A549 : IC50=0,26 uM (preliminary laboratory results). Journal of Natural Products (2011), 74(5), 1126-1131.

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Hypothemycin

Fermentation Products

What does fermentation mean? Fermentation (from latin fermentare) is generally defined as a conversion of material under aerobic or anaerobic conditions influenced by micro-organisms. "Micro-organism" is a collective term for usually ...

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