N H OH S O OH O HN OH O O

Lactacystin

Article number:

5600142

CAS No.:

133343-34-7

Formula:

C15H24N2O7S

Molecular weight:

376,43 g/mol

Lactacystin is a cell-permeable, potent and selective proteasome inhibitor. A Streptomyces metabolite that is thought to bind irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Lactacystin induces neurite outgrowth in Neuro 2a neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells.

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Lactacystin

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