Malformin C

Article number:

5500523

CAS No.:

59926-78-2

Formula:

C23H39N5O5S2

Synonyms:

5-L-Leucine-Malformin A; BRN 4896114; (-)-cyclo[D-Cys(1)-D-Cys(1)-L-Val-D-Leu-L-Leu-]

Molecular weight:

529,72 g/mol

Malformin C is a bicyclic pentapeptide containing L-leucine, D-isoleucine, L-valine, and two D-cysteines coupled with a disulfide-bond bridge. Malformins A and C, originally isolated from the culture broth of Aspergillus niger, were found to abrogate the bleomycin-induced G2 arrest in Jurkat cells with IC50 values of 480nM and 0.9nM, respectively. Malformins may be promising candidates as anti-cancer agents.

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Malformin C

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