Rebeccamycin

Article number:

5600063

CAS No.:

93908-02-2

Formula:

C27H21Cl2N3O7

Chemical description:

1,11-dichloro-12-(4-O-methyl-ß-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione

Synonyms:

7,10-dichloro-8-(3,4-dihydroxy-6-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-2-yl)-8,9-dihydro-1H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione

Molecular weight:

570,40 g/mol

An antibiotic composed of a halogenated indolocarbazole chromophore linked via N-glycosidic bond to a glucose derivative. It intercalates into the DNA and is an inhibitor of topoisomerase I. L1210: IC50 = 100 nM (mouse); K562: IC50 = 200 nM (human); A549: IC50 = 300 nM (human); B16 melanoma cells: IC50 = 480 nM (mouse); P388 leukemia cells: IC50 = 500 nM. Potential mode of action/Key words: Targeting DNA, Topoisomerase I inhibitor, Antibiotic

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Rebeccamycin

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