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Sandramycin is a high molecular weight, symmetric, cyclic depsipeptide belonging to the quinomycyn class produced by Kribbella sp. Sandramycin is described to bisintercalate DNA strands through its two pendant quinoline moeities. This bisintercalation mechanism translates to a potent antitumor activity correlated with Sandramycin. Some EC50 values in different cell lines: HCT-15: 4.0 x 10-9; HL-60: 3.6 x 10-9; Raji: 7.5 x 10-10.
Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...
What does fermentation mean? Fermentation (from latin fermentare) is generally defined as a conversion of material under aerobic or anaerobic conditions influenced by micro-organisms. "Micro-organism" is a collective term for usually ...