N N N N N N N N NH N H N H N H O O O O O O O O O O O O O O HO HO

Sandramycin

Article number:

5500656

CAS No.:

100940-65-6

Formula:

C60H76N12O16

Molecular weight:

1221,32 g/mol

Sandramycin is a high molecular weight, symmetric, cyclic depsipeptide belonging to the quinomycyn class produced by Kribbella sp. Sandramycin is described to bisintercalate DNA strands through its two pendant quinoline moeities. This bisintercalation mechanism translates to a potent antitumor activity correlated with Sandramycin. Some EC50 values in different cell lines: HCT-15: 4.0 x 10-9; HL-60: 3.6 x 10-9; Raji: 7.5 x 10-10.

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Sandramycin

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