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Wortmannin
Article number:
5500848
CAS No.:
19545-26-7
Formula:
C23H24O8
Chemical description:
(1alpha,11alpha)-11-(Acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan-3,7,17-trione
Synonyms:
BRN 0067676, NSC 627609, Antibiotic SL-2052, Wartmannin, Wortmannin, KY 12420
Molecular weight:
428,44 g/mol
Wortmannin is a potent and specific phosphatidylinositol 3-kinase inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Origin: Talaromyces (Penicillium) wortmannii
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