O O O O O H O O O

Wortmannin

Article number:

5500848

CAS No.:

19545-26-7

Formula:

C23H24O8

Chemical description:

(1alpha,11alpha)-11-(Acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan-3,7,17-trione

Synonyms:

BRN 0067676, NSC 627609, Antibiotic SL-2052, Wartmannin, Wortmannin, KY 12420

Molecular weight:

428,44 g/mol

Wortmannin is a potent and specific phosphatidylinositol 3-kinase inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Origin: Talaromyces (Penicillium) wortmannii

Inform about
Wortmannin

Protein Kinase Inhibitors

Protein kinases are enzymes that transfer phosphate groups from high-energy donors (typically nucleoside triphosphates) to surface exposed Serine, Threonine or Tyrosine side chains of other proteins and thus alter their ...

Read more