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BRN 0067676, NSC 627609, Antibiotic SL-2052, Wartmannin, Wortmannin, KY 12420
Wortmannin is a potent and specific phosphatidylinositol 3-kinase inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Origin: Talaromyces (Penicillium) wortmannii
Selman Waksman defined the term antibiotic in 1942 to describe any substance produced by a microorganism that is antagonistic to the growth of other microorganisms in high dilution. While this ...
What does fermentation mean? Fermentation (from latin fermentare) is generally defined as a conversion of material under aerobic or anaerobic conditions influenced by micro-organisms. "Micro-organism" is a collective term for usually ...
Protein Kinase Inhibitors
Protein kinases are enzymes that transfer phosphate groups from high-energy donors (typically nucleoside triphosphates) to surface exposed Serine, Threonine or Tyrosine side chains of other proteins and thus alter their ...