Active ingredient of the month November: histamine dihydrochloride

The active ingredient of the month for November is histamine dihydrochloride. The main area of application for this is the treatment of acute myeloid leukemia (AML) in combination with interleukin-2 (IL-2).

Histamine dihydrochloride is mainly used in maintenance therapy for adult patients with AML who are in initial remission. It is administered in specific treatment cycles, often in combination with IL-2. This is intended to strengthen the immune response on the one hand and prevent the recurrence of the disease on the other.

Effective in myeloid leukemia

Histamine dihydrochloride inhibits the production of reactive oxygen species (ROS), which are produced by certain immune cells. These ROS can impair the function of lymphocytes, which are of great importance for fighting leukemia cells. By inhibiting ROS production, histamine dihydrochloride protects lymphocytes while optimizing their ability to destroy leukemia cells.

The active ingredient is administered in the form of subcutaneous injections. The therapy consists of several cycles. Each cycle lasts 21 days and includes a treatment-free period. Histamine dihydrochloride is an important component in the treatment of AML in the form of targeted immunotherapy.

Also important for allergy diagnostics and biomedical research

In addition to cancer therapy, there are other areas of application for this active substance. It plays a major role in allergy diagnostics and biomedical research.

• Prick tests: Here, histamine dihydrochloride is used as a positive control to diagnose allergic reactions.
• Research: In research, it is intended to demonstrate the role of histamine in various physiological processes, for example in the study of reactions to antigens.
• Orthograde Neurotransmitter: Histamine dihydrochloride is used as an orthograde neurotransmitter to generate excitatory postsynaptic potentials.

⇒ If you are interested in Histamine Dihydrochloride, please do not hesitate to contact us.